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Inoue T, Shinnakasu R, Kawai C, Ise W, Kawakami E, Sax N, Oki T, Kitamura T, Yamashita K, Fukuyama H, Kurosaki T.

Exit from germinal center to become quiescent memory B cells depends on metabolic reprograming and provision of a survival signal.

J Exp Med.

2021 218(1): e20200866.

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Fukuyama H, Shinnakasu R, Kurosaki T.

Influenza vaccination strategies targeting the hemagglutinin stem region.

Immunol Rev.

296(1):132-141.

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Fujii K, Tanaka S, Hasegawa T, Narazaki M, Kumanogoh A, Koseki H, Kurosaki T, Ise W.

Tet DNA demethylase is required for plasma cell differentiation by controlling expression levels of IRF4.

Int Immunol.

2020 32(10):683-690.

Pubmed

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Tanaka S, Ise W, Inoue T, Ito A, Ono C, Shima Y, Sakakibara S, Nakayama M, Fujii K, Miura I, Sharif J, Koseki H, Koni PA, Raman I, Li QZ, Kubo M, Fujiki K, Nakato R, Shirahige K, Araki H, Miura F, Ito T, Kawakami E, Baba Y, Kurosaki T.

Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity.

Nat Immunol.

2020 21(8):950-961.

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Mesin L, Schiepers A, Ersching J, Barbulescu A, Cavazzoni CB, Angelini A, Okada T, Kurosaki T, Victora GD.

Restricted Clonality and Limited Germinal Center Reentry Characterize Memory B Cell Reactivation by Boosting.

Cell.

2020 180(1):92-106.e11.

Pubmed

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Sidwell T, Liao Y, Garnham AL, Vasanthakumar A, Gloury R, Blume J, Teh PP, Chisanga D, Thelemann C, de Labastida Rivera F, Engwerda CR, Corcoran L, Kometani K, Kurosaki T, Smyth GK, Shi W, Kallies A.

Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis.

Nat. Commun.

2020 11(1):252.

Pubmed

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Sato R, Makino-Okamura C, Lin Q, Wang M, Shoemaker J, Kurosaki T, Fukuyama H.

Repurposing the Psoriasis Drug Oxarol to an ointment adjuvant for the influenza vaccine.

Int Immunol.

2020 [Epub ahead of print]

Pubmed

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Usui R, Yabe D, Fauzi M, Goto H, Botagarova A, Tokumoto S, Tatsuoka H, Tahara Y, Kobayashi S, Manabe T, Baba Y, Kurosaki T, Herrera PL, Ogura M, Nagashima K, Inagaki N.

GPR40 activation initiates store-operated Ca2+ entry and potentiates insulin secretion via the IP3R1/STIM1/Orai1 pathway in pancreatic β-cells.

Sci. Rep.

2019 9(1):15562.

Pubmed

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Adachi Y, Tonouchi K, Nithichanon A, Kuraoka M, Watanabe A, Shinnakasu R, Asanuma H, Ainai A, Ohmi Y, Yamamoto T, Ishii KJ, Hasegawa H, Takeyama H, Lertmemongkolchai G, Kurosaki T, Ato M, Kelsoe G, Takahashi Y.

Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies.

Nat. Commun.

2019 10(1):3883.

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Leach S, Shinnakasu R, Adachi Y, Momota M, Makino-Okamura C, Yamamoto T, Ishii KJ, Fukuyama H, Takahashi Y, Kurosaki T.

Requirement for memory B cell activation in protection from heterologous influenza virus reinfection.

Int. Immunol.

2019 31(12):771-779.

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Lee MSJ, Natsume-Kitatani Y, Temizoz B, Fujita Y, Konishi A, Matsuda K, Igari Y, Tsukui T, Kobiyama K, Kuroda E, Onishi M, Marichal T, Ise W, Inoue T, Kurosaki T, Mizuguchi K, Akira S, Ishii KJ, Coban C.

B cell-intrinsic MyD88 signaling controls IFN-γ-mediated early IgG2c class switching in mice in response to a particulate adjuvant.

Eur. J. Immunol.

2019 49(9):1433-1440.

Pubmed

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Kong MS, Hashimoto-Tane A, Kawashima Y, Sakuma M, Yokosuka T, Kometani K, Onishi R, Carpino N, Ohara O, Kurosaki T, Phua KK, Saito T.

Inhibition of T cell activation and function by the adaptor protein CIN85.

Sci. Signal.

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Ise W, Kurosaki T.

Plasma cell differentiation during the germinal center reaction.

Immunol. Rev.

2019 288(1):64-74.

Pubmed

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Edwards CL, de Oca MM, de Labastida Rivera F, Kumar R, Ng SS, Wang Y, Amante FH, Kometani K, Kurosaki T, Sidwell T, Kallies A, Engwerda CR.

The Role of BACH2 in T Cells in Experimental Malaria Caused by Plasmodium chabaudi chabaudi AS. 2018

Front. Immunol.

2018 9:2578

Pubmed

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Tanaka S, Jiang Y, Martinez GJ, Tanaka K, Yan X, Kurosaki T, Kaartinen V, Feng XH, Tian Q, Wang X, Dong C.

Trim33 mediates the proinflammatory function of Th17 cells.

J. Exp. Med.

2018　215(7):1853-1868.

Pubmed

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Kayama H, Kohyama M, Okuzaki D, Motooka D, Barman S, Okumura R, Muneta M, Hoshino K, Sasaki I, Ise W, Matsuno H, Nishimura J, Kurosaki T, Nakamura S, Arase H, Kaisho T, Takeda K.

Heme ameliorates dextran sodium sulfate-induced colitis through providing intestinal macrophages with noninflammatory profiles.

Proc. Natl. Acad. Sci. U S A

2018　 115(33):8418-8423.

Pubmed

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Mendoza P, Martínez-Martín N, Bovolenta ER, Reyes-Garau D, Hernansanz-Agustín P, Delgado P, Diaz-Muñoz MD, Oeste CL, Fernández-Pisonero I, Castellano E, Martínez-Ruiz A, Alonso-Lopez D, Santos E, Bustelo XR, Kurosaki T, Alarcón B.

R-Ras2 is required for germinal center formation to aid B cells during energetically demanding processes.

Sci. Signal.

2018　 11(532).

Pubmed

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Raju S, Kometani K, Kurosaki T, Shaw AS, Egawa T.

The adaptor molecule CD2AP in CD4 T cells modulates differentiation of follicular helper T cells during chronic LCMV infection.

PLoS Pathog.

2018　14(5):e1007053. eCollection.

Pubmed

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Ise W, Fujii K, Shiroguchi K, Ito A, Kometani K, Takeda K, Kawakami E, Yamashita K, Suzuki K, Okada T, Kurosaki T.

T Follicular Helper Cell-Germinal Center B Cell Interaction Strength Regulates Entry into Plasma Cell or Recycling Germinal Center Cell Fate.

Immunity.

2018 48(4):702-715.e4.

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Inoue T, Moran I, Shinnakasu R, Phan TG, Kurosaki T.

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Herndler-Brandstetter D, Ishigame H, Shinnakasu R, Plajer V, Stecher C, Zhao J, Lietzenmayer M, Kroehling L, Takumi A, Kometani K, Inoue T, Kluger Y, Kaech SM, Kurosaki T, Okada T, Flavell RA.

KLRG1+ Effector CD8+ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity.

Immunity.

2018 48(4):716-729.e8.

Pubmed

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Ohba T, Watanabe H, Murakami M, Iino K, Adachi T, Baba Y, Kurosaki T, Ono K, Ito H.

Stromal interaction molecule 1 haploinsufficiency causes maladaptive response to pressure overload.

PLoS One.

2017　12(11):e0187950.

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Ebina-Shibuya R, Matsumoto M, Kuwahara M, Jang KJ, Sugai M, Ito Y, Funayama R, Nakayama K, Sato Y, Ishii N, Okamura Y, Kinoshita K, Kometani K, Kurosaki T, Muto A, Ichinose M, Yamashita M, Igarashi K.

Inflammatory responses induce an identity crisis of alveolar macrophages, leading to pulmonary alveolar proteinosis.

J Biol Chem.

2017　292(44):18098-18112.

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Wing JB, Kitagawa Y, Locci M, Hume H, Tay C, Morita T, Kidani Y, Matsuda K, Inoue T, Kurosaki T, Crotty S, Coban C, Ohkura N, Sakaguchi S.

A distinct subpopulation of CD25- T-follicular regulatory cells localizes in the germinal centers

Proc Natl Acad Sci U S A.

2017　114(31):E6400-E6409.

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Igarashi K, Kurosaki T, Roychoudhuri R

BACH transcription factors in innate and adaptive immunity.

Nat Rev Immunol.

2017 17(7):437-450.

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Inoue T, Shinnakasu R, Ise W, Kawai C, Egawa T, Kurosaki T.

The transcription factor Foxo1 controls germinal center B cell proliferation in response to T cell help.

J Exp Med.

2017 214(4):1181-1198.

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Shinnakasu R,Kurosaki T.

Regulation of memory B and plasma cell differentiation.

Curr Opin Immunol.

2017 45:126-131.

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Lim HM, Woon H, Han JW, Baba Y, Kurosaki T, Lee MG, Kim JY.

UDP-Induced Phagocytosis and ATP-Stimulated Chemotactic Migration Are Impaired in STIM1-/- Microglia In Vitro and In Vivo.

Mediators Inflamm.

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Ogura M, Inoue T, Yamaki J, Homma MK, Kurosaki T, Homma Y.

Mitochondrial reactive oxygen species suppress humoral immune response through reduction of CD19 expression in B cells in mice.

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2017 47(2):406-418.

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Kuroda E, Ozasa K, Temizoz B, Ohata K, Koo CX, Kanuma T, Kusakabe T, Kobari S, Horie M, Morimoto Y, Nakajima S, Kabashima K, Ziegler SF, Iwakura Y, Ise W, Kurosaki T, Nagatake T, Kunisawa J, Takemura N, Uematsu S, Hayashi M, Aoshi T, Kobiyama K, Coban C, Ishii KJ.

Inhaled Fine Particles Induce Alveolar Macrophage Death and Interleukin-1α Release to Promote Inducible Bronchus-Associated Lymphoid Tissue Formation.

Immunity.

2016　45(6):1299-1310.

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Ikawa T, Masuda K, Endo TA, Endo M, Isono K, Koseki Y, Nakagawa R, Kometani K, Takano J, Agata Y, Katsura Y, Kurosaki T, Vidal M, Koseki H, Kawamoto H.

Conversion of T cells to B cells by inactivation of polycomb-mediated epigenetic suppression of the B-lineage program.

Genes Dev.

2016 30(22):2475-2485.

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Inui M, Sugahara-Tobinai A, Fujii H, Itoh-Nakadai A, Fukuyama H, Kurosaki T, Ishii T, Harigae H, Takai T.　

Tolerogenic immunoreceptor ILT3/LILRB4 paradoxically marks pathogenic auto-antibody-producing plasmablasts and plasma cells in non-treated SLE.

Int Immunol.

2016　(12):597-604

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Shinohara H, Nagashima T, Cascalho MI, Kurosaki T.

TAK1 maintains the survival of immunoglobulin λ-chain-positive B cells.

Genes Cells.

2016　 (11):1233-1243.

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Ishikawa E, Kosako H, Yasuda T, Ohmuraya M, Araki K, Kurosaki T, Saito T, Yamasaki S.

Protein kinase D regulates positive selection of CD4⁺ thymocytes through phosphorylation of SHP-1.

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2016　 7:12756.

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Kuwahara M, Ise W, Ochi M, Suzuki J, Kometani K, Maruyama S, Izumoto M, Matsumoto A, Takemori N, Takemori A, Shinoda K, Nakayama T, Ohara O, Yasukawa M, Sawasaki T, Kurosaki T, Yamashita M.

Bach2-Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop.

Nat Commun.

2016　7:12596.

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Shinohara H, Yasuda T, Kurosaki T.

TAK1 adaptor proteins, TAB2 and TAB3, link the signalosome to B-cell receptor-induced IKK activation.

FEBS Lett.

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Shinohara H, Kurosaki T.

Negative role of TAK1 in marginal zone B-cell development incidental to NF-κB noncanonical pathway activation.

Immunol Cell Biol.

2016 94(9):821-829.

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Morimoto K, Baba Y, Shinohara H, Kang S, Nojima S, Kimura T, Ito D, Yoshida Y, Maeda Y, Sarashina-Kida H, Nishide M, Hosokawa T, Kato Y, Hayama Y, Kinehara Y, Okuno T, Takamatsu H, Hirano T, Shima Y, Narazaki M, Kurosaki T, Toyofuku T, Kumanogoh A.

LRRK1 is critical in the regulation of B-cell responses and CARMA1-dependent NF-κB activation.

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Shinnakasu, R., Inoue, T., Kometani, K., Moriyama, S., Adachi, Y., Nakayama, M., Takahashi, Y., Fukuyama, H., Okada, T.,Kurosaki, T.

Regulated selection of germinal center cells into the memory B cell compartment.

Nat Immunol.

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Onodera T, Hosono A, Odagiri T, Tashiro M, Kaminogawa S, Okuno Y, Kurosaki T, Ato M, Kobayashi K, Takahashi Y.

Whole-Virion Influenza Vaccine Recalls an Early Burst of High-Affinity Memory B Cell Response through TLR Signaling.

J Immunol.

2016 196(10):4172-84.

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Ohmi, Y., Ise, W., Harazono, A., Takakura, D., Fukuyama, H., Baba, Y., Narazaki, M., Shoda, H., Takahashi, N., Ohkawa, Y., Ji, S., Sugiyama, F., Fujio, K., Kumanogoh, A., Yamamoto, K., Kawasaki, N., Kurosaki, T., Takahashi, Y., Furukawa, K.

Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis.

Nat. Commun.

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Kaileh M, Vazquez E, MacFarlane AW 4th, Campbell K, Kurosaki T, Siebenlist U, Sen R.

mTOR-Dependent and Independent Survival Signaling by PI3K in B Lymphocytes.

PLoS One.

2016 11(1):e0146955.

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Adachi Y, Onodera T, Yamada Y, Daio R, Tsuiji M, Inoue T, Kobayashi K, Kurosaki T, Ato M, Takahashi Y.

Distinct germinal center selection at local sites shapes memory B cell response to viral escape.

J Exp Med.

2015　212(10):1709-23.

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Inoue, T., Morita, M., Hijikata, A., Fukuda-Yuzawa, Y., Adachi, S., Isono, K., Ikawa, T., Kawamoto, H., Koseki, H., Natsume, T., Fukao, T., Ohara, O., Yamamoto, T., Kurosaki, T.

CNOT3 contributes to early B cell development by controlling Igh rearrangement and p53 mRNA stability.

J Exp Med.

2015 212(9):1465-79.

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Onishi, M., Ozasa, K., Kobiyama, K., Ohata, K., Kitano, M., Taniguchi, K., Homma, T., Kobayashi, M., Sato, A., Katakai, Y., Yasutomi, Y., Wijaya, E., Igarashi, Y., Nakatsu, N., Ise, W., Inoue, T., Yamada, H., Vandenbon, A., Standley, D.M., Kurosaki, T., Coban, C., Aoshi, T., Kuroda, E., Ishii, K.J.

Tolerogenic immunoreceptor ILT3/LILRB4 paradoxically marks pathogenic auto-antibody-producing plasmablasts and plasma cells in non-treated SLE.

J Immunol.

2015　194(6):2673-82

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Shanmughapriya, S., Rajan, S., Hoffman, N.E., Zhang, X., Guo. S., Kolesar, J.E., Hines, K.J., Ragheb, J., Jog, N.R., Caricchio, R., Baba, Y., Zhou, Y., Kaufman, B.A., Cheung, J.Y., Kurosaki, T., Gill, D.L., Madesh, M.

Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU.

Sci Signal.

2015　 8(366):ra23.

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Uebelhart, R., Hug, E., Bach, MP., Wossning, T., Duhren-von Minden, M., Horn, AHC., Kometani, K., Kurosaki, T., Sticht, H., Reth, M., Jumaa, H.

Responsiveness of B cells is regulated by the hinge region of IgD.

Nat. Immunol.

2015　16:534-43

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Baba Y, Kurosaki T.

Bach2-Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop.

Curr Top Microbiol Immunol.

2015 393:143-174.Review

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Kurosaki, T., Kometani, K., Ise, W.

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Nat Rev Immunol.

2015 15:149-59.Review

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Kometani, K., Kurosaki,T.

Differentiation and maintenance of long-lived plasma cells.

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2015 33:64-9.Review

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Baba, Y., Matsumoto, M., Kurosaki, T.

Signals controlling the development and activity of regulatory B-lineage cells.

Nat Immunol.

2015 27(10):487-93.Review

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Matsumoto, M., Baba, A., Yokota, T., Nishikawa, H., Ohkawa, Y., Kayama, H., Kallies, A., Nutt, S.L., Sakaguchi, S., Takeda, K., Kurosaki, T., Baba, Y.

Interleukin-10-Producing Plasmablasts Exert Regulatory Function in Autoimmune Inflammation.

Immunity.

2014　41:1040-51

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Ise, W., Inoue, T., McLachlan, J.B., Kometani, K., Kubo, M., Okada, T. Kurosaki, T.

Memory B cells contribute to rapid Bcl6 expression by memory TFH cells.

Proc. Natl. Acad. U.S.A.

2014 111:11792-7.

Pubmed

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Shinohara, H., Behar, M., Inoue, K., Hiroshima, M., Yasuda, T., Nagashima, T., Kimura, S., Sanjo, H., Maeda, S., Yumoto, N., Ki, Sewon, Akira, S., Sako, Y., *Hoffmann, A., *Kurosaki, T., *Okada-Hatakeyama, M.(*co-corresponding authors)

Positive Feedback Within a Kinase Signaling Complex Functions as a Switch Mechanism for NF-κB Activation.

Science.

2014　344:760-764.

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Baba, Y., Matsumoto, M., Kurosaki, T.　

Calcium signaling in B cells: regulation of cytosolic Ca2+ increase and its sensor molecules, STIM1 and STIM2.

Mol Immunol.

2014　 62:339-43.Review

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Kometani, K., Nakagawa, R., Shinnakasu, R., Kaji, T., Rybouchkin, A., Moriyama, S., Furukawa, K., Koseki, H., Takemori, T. and Kurosaki, T.

Repression of the Transcription Factor Bach2 Contributes to Predisposition of IgG1 Memory B Cells toward Plasma Cell Differentiation.

Immunity.

2013　39, 136-147

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Kometani, K., Yamada, T., Sasaki, Y., Yokosuka, T., Saito, T., Rajewsky, K., Ishiai, M., Hikida, M. and Kurosaki, T.

CIN85 drives B cell responses by linking BCR signals to the canonical NF-κB pathway.

J. Exp. Med.

2011 208(7), 1447-1457

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Matsumoto, M., Fujii, Y., Baba, A., Hikida, M., Kurosaki, T. and Baba, Y.

The calcium sensors STIM1 and STIM2 control B cell regulatory function through IL-10 production.

Immunity.

2011 34, 703-714

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Yasuda T., Kometani, K., Takahashi, N., Imai, Y., Aiba, Y. and Kurosaki, T.

ERKs Induce Expression of the Transcriptional Repressor Blimp-1 and Subsequent Plasma Cell Differentiation.

Sci. Signal.

2011 4, (169) ra25

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Baba, Y. and Kurosaki, T.

Impact of Ca2+ signaling on B cell function.

Trends in Immunol.

2011 32(12)589-594 Review

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Regulation of BCR Signaling.

Mol. Immunol.

2011 48, 1287-1291 Review

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