大阪大学免疫学フロンティア研究センター 分化制御研究室Laboratory of Lymphocyte Differentiation   Immunology Frontier Research Center, Osaka University

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  • 2023

    3

    Yada Y, Matsumoto M, Inoue T, Baba A, Higuchi R, Kawai C, Yanagisawa M, Kitamura D, Ohga S, Kurosaki T, Baba Y.

    STIM-mediated calcium influx regulates maintenance and selection of germinal center B cells.

    J Exp Med.

    2024 221(1):e20222178.

    Pubmed

    2

    Inoue K, Yasuda T, Baba Y, Yamamoto T, Kurosaki T, Shinohara H.

    Regulation mechanisms of CARMA1-Bcl10-MALT1 complex assembly inferred from the analysis of TRAF6-deficient cells.

    Genes Cells.

    2023 28(6):411-421.

    Pubmed

    1

    Onodera T, Sax N, Sato T, Adachi Y, Kotaki R, Inoue T, Shinnakasu R, Nakagawa T, Fukushi S, Terooatea T, Yoshikawa M, Tonouchi K, Nagakura T, Moriyama S, Matsumura T, Isogawa M, Terahara K, Takano T, Sun L, Nishiyama A, Omoto S, Shinkai M, Kurosaki T, Yamashita K, Takahashi Y.

    CD62L expression marks SARS-CoV-2 memory B cell subset with preference for neutralizing epitopes.

    Sci Adv.

    2023 9(24):eadf0661.

    Pubmed

  • 2022

    12

    Koike T, Fujii K, Kometani K, Butler NS, Funakoshi K, Yari S, Kikuta J, Ishii M, Kurosaki T, Ise W.

    Progressive differentiation toward the long-lived plasma cell compartment in the bone marrow.

    J Exp Med.

    2023 220(2):e20221717.

    Pubmed

    11

    Inoue T, Shinnakasu R, Kawai C, Yamamoto H, Sakakibara S, Ono C, Itoh Y, Terooatea T, Yamashita K, Okamoto T, Hashii N, Ishii-Watabe A, Butler NS, Matsuura Y, Matsumoto H, Otsuka S, Hiraoka K, Teshima T, Murakami M, Kurosaki T.

    Antibody feedback contributes to facilitating the development of Omicron-reactive memory B cells in SARS-CoV-2 mRNA vaccinees.

    J Exp Med.

    2023 220(2):e20221786.

    Pubmed

    10

    Imianowski CJ, Whiteside SK, Lozano T, Evans AC, Benson JD, Courreges CJF, Sadiyah F, Lau CM, Zandhuis ND, Grant FM, Schuijs MJ, Vardaka P, Kuo P, Soilleux EJ, Yang J, Sun JC, Kurosaki T, Okkenhaug K, Halim TYF, Roychoudhuri R.

    BACH2 restricts NK cell maturation and function, limiting immunity to cancer metastasis.

    J Exp Med.

    2022 219(12):e20211476.

    Pubmed

    9

    Itahashi K, Irie T, Yuda J, Kumagai S, Tanegashima T, Lin YT, Watanabe S, Goto Y, Suzuki J, Aokage K, Tsuboi M, Minami Y, Ishii G, Ohe Y, Ise W, Kurosaki T, Suzuki Y, Koyama S, Nishikawa H.

    BATF epigenetically and transcriptionally controls the activation program of regulatory T cells in human tumors.

    Sci Immunol.

    2022 7(76):eabk0957.

    Pubmed

    8

    Li S, Bern MD, Miao B, Fan C, Xing X, Inoue T, Piersma SJ, Wang T, Colonna M, Kurosaki T, Yokoyama WM.

    The transcription factor Bach2 negatively regulates murine natural killer cell maturation and function.

    Elife.

    2022 11:e77294.

    Pubmed

    7

    Tanaka S, Ise W, Baba Y, Kurosaki T.

    Silencing and activating anergic B cells.

    Immunol Rev.

    2022 307(1):43-52.

    Pubmed

    6

    Zhang Y, Garcia-Ibanez L, Ulbricht C, Lok LSC, Pike JA, Mueller-Winkler J, Dennison TW, Ferdinand JR, Burnett CJM, Yam-Puc JC, Zhang L, Alfaro RM, Takahama Y, Ohigashi I, Brown G, Kurosaki T, Tybulewicz VLJ, Rot A, Hauser AE, Clatworthy MR, Toellner KM.

    Recycling of memory B cells between germinal center and lymph node subcapsular sinus supports affinity maturation to antigenic drift.

    Nat Commun.

    2022 13(1):2460.

    Pubmed

    5

    Liu Q, Umemoto E, Morita N, Kayama H, Baba Y, Kurosaki T, Okumura R, Takeda K.

    Pyruvate enhances oral tolerance via GPR31.

    Int Immunol.

    2022 34(7):343-352.

    Pubmed

    4

    Tsao HW, Kaminski J, Kurachi M, Barnitz RA, DiIorio MA, LaFleur MW, Ise W, Kurosaki T, Wherry EJ, Haining WN, Yosef N.

    Batf-mediated epigenetic control of effector CD8 + T cell differentiation.

    Sci Immunol.

    2022 7(68):eabi4919.

    Pubmed

    3

    Lee MSJ, Inoue T, Ise W, Matsuo-Dapaah J, Wing JB, Temizoz B, Kobiyama K, Hayashi T, Patil A, Sakaguchi S, Simon AK, Bezbradica JS, Nagatoishi S, Tsumoto K, Inoue JI, Akira S, Kurosaki T, Ishii KJ, Coban C.

    B cell-intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice.

    J Exp Med.

    2022 219(2):e20211336.

    Pubmed

    2

    Yeh CH, Finney J, Okada T, Kurosaki T, Kelsoe G.

    Primary germinal center-resident T follicular helper cells are a physiologically distinct subset of CXCR5 hi PD-1 hi T follicular helper cells.

    Immunity.

    2022 55(2):272-289.e7.

    Pubmed

    1

    Inoue T, Shinnakasu R, Kurosaki T.

    Generation of High Quality Memory B Cells.

    Front Immunol.

    2022 12:825813.

    Pubmed

  • 2021

    7

    Shinnakasu R, Sakakibara S, Yamamoto H, Wang PH, Moriyama S, Sax N, Ono C, Yamanaka A, Adachi Y, Onodera T, Sato T, Shinkai M, Suzuki R, Matsuura Y, Hashii N, Takahashi Y, Inoue T, Yamashita K, Kurosaki T.

    Glycan engineering of the SARS-CoV-2 receptor-binding domain elicits cross-neutralizing antibodies for SARS-related viruses.

    J Exp Med.

    2021 218(12):e20211003

    Pubmed

    6

    Ise W, Kurosaki T.

    Plasma cell generation during T-cell-dependent immune responses.

    J Int Immunol.

    2021 33(12):797-801.

    Pubmed

    5

    Lu X, Hosono Y, Nagae M, Ishizuka S, Ishikawa E, Motooka D, Ozaki Y, Sax N, Maeda Y, Kato Y, Morita T, Shinnakasu R, Inoue T, Onodera T, Matsumura T, Shinkai M, Sato T, Nakamura S, Mori S, Kanda T, Nakayama EE, Shioda T, Kurosaki T, Takeda K, Kumanogoh A, Arase H, Nakagami H, Yamashita K, Takahashi Y, Yamasaki S.

    Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients.

    J Exp Med.

    218(12):e20211327.

    Pubmed

    4

    Onodera T, Kita S, Adachi Y, Moriyama S, Sato A, Nomura T, Sakakibara S, Inoue T, Tadokoro T, Anraku Y, Yumoto K, Tian C, Fukuhara H, Sasaki M, Orba Y, Shiwa N, Iwata N, Nagata N, Suzuki T, Sasaki J, Sekizuka T, Tonouchi K, Sun L, Fukushi S, Satofuka H, Kazuki Y, Oshimura M, Kurosaki T, Kuroda M, Matsuura Y, Suzuki T, Sawa H, Hashiguchi T, Maenaka K, Takahashi Y.

    A SARS-CoV-2 antibody broadly neutralizes SARS-related coronaviruses and variants by coordinated recognition of a virus-vulnerable site.

    J Immunity.

    2021 54(10):2385-2398.e10.

    Pubmed

    3

    Raju S, Xia Y, Daniel B, Yost KE, Bradshaw E, Tonc E, Verbaro DJ, Kometani K, Yokoyama WM, Kurosaki T, Satpathy AT, Egawa T.

    Identification of a T-bethi Quiescent Exhausted CD8 T Cell Subpopulation That Can Differentiate into TIM3+CX3CR1+ Effectors and Memory-like Cells.

    J Immunol.

    2021 206(12)2924-2936.

    Pubmed

    2

    Yao C, Lou G, Sun HW, Zhu Z, Sun Y, Chen Z, Chauss D, Moseman EA, Cheng J, D'Antonio MA, Shi W, Shi J, Kometani K, Kurosaki T, Wherry EJ, Afzali B, Gattinoni L, Zhu Y, McGavern DB, O'Shea JJ, Schwartzberg PL, Wu T.

    BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8+ T cells.

    Nat Immunol.

    2021 22(3):370-380.

    Pubmed

    1

    Inoue T, Shinnakasu R, Kawai C, Ise W, Kawakami E, Sax N, Oki T, Kitamura T, Yamashita K, Fukuyama H, Kurosaki T.

    Exit from germinal center to become quiescent memory B cells depends on metabolic reprograming and provision of a survival signal.

    J Exp Med.

    2021 218(1):e20200866.

    Pubmed

  • 2020

    8

    Grant FM, Yang J, Nasrallah R, Clarke J, Sadiyah F, Whiteside SK, Imianowski CJ, Kuo P, Vardaka P, Todorov T, Zandhuis N, Patrascan I, Tough DF, Kometani K, Eil R, Kurosaki T, Okkenhaug K, Roychoudhuri R.

    BACH2 drives quiescence and maintenance of resting Treg cells to promote homeostasis and cancer immunosuppression.

    J Exp Med.

    2020 217(9):e20190711.

    Pubmed

    7

    Sato R, Makino-Okamura C, Lin Q, Wang M, Shoemaker JE, Kurosaki T, Fukuyama H.

    Repurposing the psoriasis drug Oxarol to an ointment adjuvant for the influenza vaccine.

    Int Immunol.

    2020 32(8):499-507.

    Pubmed

    6

    Fukuyama H, Shinnakasu R, Kurosaki T.

    Influenza vaccination strategies targeting the hemagglutinin stem region.

    Immunol Rev.

    296(1):132-141.

    Pubmed

    5

    Fujii K, Tanaka S, Hasegawa T, Narazaki M, Kumanogoh A, Koseki H, Kurosaki T, Ise W.

    Tet DNA demethylase is required for plasma cell differentiation by controlling expression levels of IRF4.

    Int Immunol.

    2020 32(10):683-690.

    Pubmed

    4

    Tanaka S, Ise W, Inoue T, Ito A, Ono C, Shima Y, Sakakibara S, Nakayama M, Fujii K, Miura I, Sharif J, Koseki H, Koni PA, Raman I, Li QZ, Kubo M, Fujiki K, Nakato R, Shirahige K, Araki H, Miura F, Ito T, Kawakami E, Baba Y, Kurosaki T.

    Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity.

    Nat Immunol.

    2020 21(8):950-961.

    Pubmed

    3

    Mesin L, Schiepers A, Ersching J, Barbulescu A, Cavazzoni CB, Angelini A, Okada T, Kurosaki T, Victora GD.

    Restricted Clonality and Limited Germinal Center Reentry Characterize Memory B Cell Reactivation by Boosting.

    Cell.

    2020 180(1):92-106.e11.

    Pubmed

    2

    Sidwell T, Liao Y, Garnham AL, Vasanthakumar A, Gloury R, Blume J, Teh PP, Chisanga D, Thelemann C, de Labastida Rivera F, Engwerda CR, Corcoran L, Kometani K, Kurosaki T, Smyth GK, Shi W, Kallies A.

    Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis.

    Nat. Commun.

    2020 11(1):252.

    Pubmed

    1

    Sato R, Makino-Okamura C, Lin Q, Wang M, Shoemaker J, Kurosaki T, Fukuyama H.

    Repurposing the Psoriasis Drug Oxarol to an ointment adjuvant for the influenza vaccine.

    Int Immunol.

    2020 [Epub ahead of print]

    Pubmed

  • 2019

    6

    Usui R, Yabe D, Fauzi M, Goto H, Botagarova A, Tokumoto S, Tatsuoka H, Tahara Y, Kobayashi S, Manabe T, Baba Y, Kurosaki T, Herrera PL, Ogura M, Nagashima K, Inagaki N.

    GPR40 activation initiates store-operated Ca2+ entry and potentiates insulin secretion via the IP3R1/STIM1/Orai1 pathway in pancreatic β-cells.

    Sci. Rep.

    2019 9(1):15562.

    Pubmed

    5

    Adachi Y, Tonouchi K, Nithichanon A, Kuraoka M, Watanabe A, Shinnakasu R, Asanuma H, Ainai A, Ohmi Y, Yamamoto T, Ishii KJ, Hasegawa H, Takeyama H, Lertmemongkolchai G, Kurosaki T, Ato M, Kelsoe G, Takahashi Y.

    Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies.

    Nat. Commun.

    2019 10(1):3883.

    Pubmed

    4

    Leach S, Shinnakasu R, Adachi Y, Momota M, Makino-Okamura C, Yamamoto T, Ishii KJ, Fukuyama H, Takahashi Y, Kurosaki T.

    Requirement for memory B cell activation in protection from heterologous influenza virus reinfection.

    Int. Immunol.

    2019 31(12):771-779.

    Pubmed

    3

    Lee MSJ, Natsume-Kitatani Y, Temizoz B, Fujita Y, Konishi A, Matsuda K, Igari Y, Tsukui T, Kobiyama K, Kuroda E, Onishi M, Marichal T, Ise W, Inoue T, Kurosaki T, Mizuguchi K, Akira S, Ishii KJ, Coban C.

    B cell-intrinsic MyD88 signaling controls IFN-γ-mediated early IgG2c class switching in mice in response to a particulate adjuvant.

    Eur. J. Immunol.

    2019 49(9):1433-1440.

    Pubmed

    2

    Kong MS, Hashimoto-Tane A, Kawashima Y, Sakuma M, Yokosuka T, Kometani K, Onishi R, Carpino N, Ohara O, Kurosaki T, Phua KK, Saito T.

    Inhibition of T cell activation and function by the adaptor protein CIN85.

    Sci. Signal.

    2019 12(567).

    Pubmed

    1

    Ise W, Kurosaki T.

    Plasma cell differentiation during the germinal center reaction.

    Immunol. Rev.

    2019 288(1):64-74.

    Pubmed

  • 2018

    8

    Edwards CL, de Oca MM, de Labastida Rivera F, Kumar R, Ng SS, Wang Y, Amante FH, Kometani K, Kurosaki T, Sidwell T, Kallies A, Engwerda CR.

    The Role of BACH2 in T Cells in Experimental Malaria Caused by Plasmodium chabaudi chabaudi AS. 2018

    Front. Immunol.

    2018 9:2578

    Pubmed

    7

    Tanaka S, Jiang Y, Martinez GJ, Tanaka K, Yan X, Kurosaki T, Kaartinen V, Feng XH, Tian Q, Wang X, Dong C.

    Trim33 mediates the proinflammatory function of Th17 cells.

    J. Exp. Med.

    2018 215(7):1853-1868.

    Pubmed

    6

    Kayama H, Kohyama M, Okuzaki D, Motooka D, Barman S, Okumura R, Muneta M, Hoshino K, Sasaki I, Ise W, Matsuno H, Nishimura J, Kurosaki T, Nakamura S, Arase H, Kaisho T, Takeda K.

    Heme ameliorates dextran sodium sulfate-induced colitis through providing intestinal macrophages with noninflammatory profiles.

    Proc. Natl. Acad. Sci. U S A

    2018  115(33):8418-8423.

    Pubmed

    5

    Mendoza P, Martínez-Martín N, Bovolenta ER, Reyes-Garau D, Hernansanz-Agustín P, Delgado P, Diaz-Muñoz MD, Oeste CL, Fernández-Pisonero I, Castellano E, Martínez-Ruiz A, Alonso-Lopez D, Santos E, Bustelo XR, Kurosaki T, Alarcón B.

    R-Ras2 is required for germinal center formation to aid B cells during energetically demanding processes.

    Sci. Signal.

    2018  11(532).

    Pubmed

    4

    Raju S, Kometani K, Kurosaki T, Shaw AS, Egawa T.

    The adaptor molecule CD2AP in CD4 T cells modulates differentiation of follicular helper T cells during chronic LCMV infection.

    PLoS Pathog.

    2018 14(5):e1007053. eCollection.

    Pubmed

    3

    Ise W, Fujii K, Shiroguchi K, Ito A, Kometani K, Takeda K, Kawakami E, Yamashita K, Suzuki K, Okada T, Kurosaki T.

    T Follicular Helper Cell-Germinal Center B Cell Interaction Strength Regulates Entry into Plasma Cell or Recycling Germinal Center Cell Fate.

    Immunity.

    2018 48(4):702-715.e4.

    Pubmed

    2

    Inoue T, Moran I, Shinnakasu R, Phan TG, Kurosaki T.

    Generation of memory B cells and their reactivation.

    Immunol. Rev.

    2018 283(1):138-149. Review.

    Pubmed

    1

    Herndler-Brandstetter D, Ishigame H, Shinnakasu R, Plajer V, Stecher C, Zhao J, Lietzenmayer M, Kroehling L, Takumi A, Kometani K, Inoue T, Kluger Y, Kaech SM, Kurosaki T, Okada T, Flavell RA.

    KLRG1+ Effector CD8+ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity.

    Immunity.

    2018 48(4):716-729.e8.

    Pubmed

  • 2017

    8

    Ohba T, Watanabe H, Murakami M, Iino K, Adachi T, Baba Y, Kurosaki T, Ono K, Ito H.

    Stromal interaction molecule 1 haploinsufficiency causes maladaptive response to pressure overload.

    PLoS One.

    2017 12(11):e0187950.

    Pubmed

    7

    Ebina-Shibuya R, Matsumoto M, Kuwahara M, Jang KJ, Sugai M, Ito Y, Funayama R, Nakayama K, Sato Y, Ishii N, Okamura Y, Kinoshita K, Kometani K, Kurosaki T, Muto A, Ichinose M, Yamashita M, Igarashi K.

    Inflammatory responses induce an identity crisis of alveolar macrophages, leading to pulmonary alveolar proteinosis.

    J Biol Chem.

    2017 292(44):18098-18112.

    Pubmed

    6

    Wing JB, Kitagawa Y, Locci M, Hume H, Tay C, Morita T, Kidani Y, Matsuda K, Inoue T, Kurosaki T, Crotty S, Coban C, Ohkura N, Sakaguchi S.

    A distinct subpopulation of CD25- T-follicular regulatory cells localizes in the germinal centers

    Proc Natl Acad Sci U S A.

    2017 114(31):E6400-E6409.

    Pubmed

    5

    Igarashi K, Kurosaki T, Roychoudhuri R

    BACH transcription factors in innate and adaptive immunity.

    Nat Rev Immunol.

    2017 17(7):437-450.

    Pubmed

    4

    Inoue T, Shinnakasu R, Ise W, Kawai C, Egawa T, Kurosaki T.

    The transcription factor Foxo1 controls germinal center B cell proliferation in response to T cell help.

    J Exp Med.

    2017 214(4):1181-1198.

    Pubmed

    3

    Shinnakasu R,Kurosaki T.

    Regulation of memory B and plasma cell differentiation.

    Curr Opin Immunol.

    2017 45:126-131.

    Pubmed

    2

    Lim HM, Woon H, Han JW, Baba Y, Kurosaki T, Lee MG, Kim JY.

    UDP-Induced Phagocytosis and ATP-Stimulated Chemotactic Migration Are Impaired in STIM1-/- Microglia In Vitro and In Vivo.

    Mediators Inflamm.

    2017;2017:8158514.

    Pubmed

    1

    Ogura M, Inoue T, Yamaki J, Homma MK, Kurosaki T, Homma Y.

    Mitochondrial reactive oxygen species suppress humoral immune response through reduction of CD19 expression in B cells in mice.

    Eur J Immunol.

    2017 47(2):406-418.

    Pubmed

  • 2016

    13

    Kuroda E, Ozasa K, Temizoz B, Ohata K, Koo CX, Kanuma T, Kusakabe T, Kobari S, Horie M, Morimoto Y, Nakajima S, Kabashima K, Ziegler SF, Iwakura Y, Ise W, Kurosaki T, Nagatake T, Kunisawa J, Takemura N, Uematsu S, Hayashi M, Aoshi T, Kobiyama K, Coban C, Ishii KJ.

    Inhaled Fine Particles Induce Alveolar Macrophage Death and Interleukin-1α Release to Promote Inducible Bronchus-Associated Lymphoid Tissue Formation.

    Immunity.

    2016 45(6):1299-1310.

    Pubmed

    12

    Ikawa T, Masuda K, Endo TA, Endo M, Isono K, Koseki Y, Nakagawa R, Kometani K, Takano J, Agata Y, Katsura Y, Kurosaki T, Vidal M, Koseki H, Kawamoto H.

    Conversion of T cells to B cells by inactivation of polycomb-mediated epigenetic suppression of the B-lineage program.

    Genes Dev.

    2016 30(22):2475-2485.

    Pubmed

    11

    Inui M, Sugahara-Tobinai A, Fujii H, Itoh-Nakadai A, Fukuyama H, Kurosaki T, Ishii T, Harigae H, Takai T. 

    Tolerogenic immunoreceptor ILT3/LILRB4 paradoxically marks pathogenic auto-antibody-producing plasmablasts and plasma cells in non-treated SLE.

    Int Immunol.

    2016 (12):597-604

    Pubmed

    10

    Shinohara H, Nagashima T, Cascalho MI, Kurosaki T.

    TAK1 maintains the survival of immunoglobulin λ-chain-positive B cells.

    Genes Cells.

    2016  (11):1233-1243.

    Pubmed

    9

    Ishikawa E, Kosako H, Yasuda T, Ohmuraya M, Araki K, Kurosaki T, Saito T, Yamasaki S.

    Protein kinase D regulates positive selection of CD4⁺ thymocytes through phosphorylation of SHP-1.

    Nat Commun.

    2016  7:12756.

    Pubmed

    8

    Kuwahara M, Ise W, Ochi M, Suzuki J, Kometani K, Maruyama S, Izumoto M, Matsumoto A, Takemori N, Takemori A, Shinoda K, Nakayama T, Ohara O, Yasukawa M, Sawasaki T, Kurosaki T, Yamashita M.

    Bach2-Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop.

    Nat Commun.

    2016 7:12596.

    Pubmed

    7

    Shinohara H, Yasuda T, Kurosaki T.

    TAK1 adaptor proteins, TAB2 and TAB3, link the signalosome to B-cell receptor-induced IKK activation.

    FEBS Lett.

    2016 590(18):3264-9.

    Pubmed

    6

    Shinohara H, Kurosaki T.

    Negative role of TAK1 in marginal zone B-cell development incidental to NF-κB noncanonical pathway activation.

    Immunol Cell Biol.

    2016 94(9):821-829.

    Pubmed

    5

    Morimoto K, Baba Y, Shinohara H, Kang S, Nojima S, Kimura T, Ito D, Yoshida Y, Maeda Y, Sarashina-Kida H, Nishide M, Hosokawa T, Kato Y, Hayama Y, Kinehara Y, Okuno T, Takamatsu H, Hirano T, Shima Y, Narazaki M, Kurosaki T, Toyofuku T, Kumanogoh A.

    LRRK1 is critical in the regulation of B-cell responses and CARMA1-dependent NF-κB activation.

    Sci Rep.

    2016 6:25738.

    Pubmed

    4

    Shinnakasu, R., Inoue, T., Kometani, K., Moriyama, S., Adachi, Y., Nakayama, M., Takahashi, Y., Fukuyama, H., Okada, T.,Kurosaki, T.

    Regulated selection of germinal center cells into the memory B cell compartment.

    Nat Immunol.

    2016 17(7):861-9.

    Pubmed

    3

    Onodera T, Hosono A, Odagiri T, Tashiro M, Kaminogawa S, Okuno Y, Kurosaki T, Ato M, Kobayashi K, Takahashi Y.

    Whole-Virion Influenza Vaccine Recalls an Early Burst of High-Affinity Memory B Cell Response through TLR Signaling.

    J Immunol.

    2016 196(10):4172-84.

    Pubmed

    2

    Ohmi, Y., Ise, W., Harazono, A., Takakura, D., Fukuyama, H., Baba, Y., Narazaki, M., Shoda, H., Takahashi, N., Ohkawa, Y., Ji, S., Sugiyama, F., Fujio, K., Kumanogoh, A., Yamamoto, K., Kawasaki, N., Kurosaki, T., Takahashi, Y., Furukawa, K.

    Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis.

    Nat. Commun.

    2016 7:11205.

    Pubmed

    1

    Kaileh M, Vazquez E, MacFarlane AW 4th, Campbell K, Kurosaki T, Siebenlist U, Sen R.

    mTOR-Dependent and Independent Survival Signaling by PI3K in B Lymphocytes.

    PLoS One.

    2016 11(1):e0146955.

    Pubmed

  • 2015

    10

    Adachi Y, Onodera T, Yamada Y, Daio R, Tsuiji M, Inoue T, Kobayashi K, Kurosaki T, Ato M, Takahashi Y.

    Distinct germinal center selection at local sites shapes memory B cell response to viral escape.

    J Exp Med.

    2015 212(10):1709-23.

    Pubmed

    9

    Inoue, T., Morita, M., Hijikata, A., Fukuda-Yuzawa, Y., Adachi, S., Isono, K., Ikawa, T., Kawamoto, H., Koseki, H., Natsume, T., Fukao, T., Ohara, O., Yamamoto, T., Kurosaki, T.

    CNOT3 contributes to early B cell development by controlling Igh rearrangement and p53 mRNA stability.

    J Exp Med.

    2015 212(9):1465-79.

    Pubmed

    8

    Onishi, M., Ozasa, K., Kobiyama, K., Ohata, K., Kitano, M., Taniguchi, K., Homma, T., Kobayashi, M., Sato, A., Katakai, Y., Yasutomi, Y., Wijaya, E., Igarashi, Y., Nakatsu, N., Ise, W., Inoue, T., Yamada, H., Vandenbon, A., Standley, D.M., Kurosaki, T., Coban, C., Aoshi, T., Kuroda, E., Ishii, K.J.

    Tolerogenic immunoreceptor ILT3/LILRB4 paradoxically marks pathogenic auto-antibody-producing plasmablasts and plasma cells in non-treated SLE.

    J Immunol.

    2015 194(6):2673-82

    Pubmed

    7

    Shanmughapriya, S., Rajan, S., Hoffman, N.E., Zhang, X., Guo. S., Kolesar, J.E., Hines, K.J., Ragheb, J., Jog, N.R., Caricchio, R., Baba, Y., Zhou, Y., Kaufman, B.A., Cheung, J.Y., Kurosaki, T., Gill, D.L., Madesh, M.

    Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU.

    Sci Signal.

    2015  8(366):ra23.

    Pubmed

    6

    Uebelhart, R., Hug, E., Bach, MP., Wossning, T., Duhren-von Minden, M., Horn, AHC., Kometani, K., Kurosaki, T., Sticht, H., Reth, M., Jumaa, H.

    Responsiveness of B cells is regulated by the hinge region of IgD.

    Nat. Immunol.

    2015 16:534-43

    Pubmed

    5

    Baba Y, Kurosaki T.

    Bach2-Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop.

    Curr Top Microbiol Immunol.

    2015 393:143-174.Review

    Pubmed

    4

    Kurosaki, T., Kometani, K., Ise, W.

    Memory B cells.

    Nat Rev Immunol.

    2015 15:149-59.Review

    Pubmed

    3

    Kometani, K., Kurosaki,T.

    Differentiation and maintenance of long-lived plasma cells.

    Opin. Immunol.

    2015 33:64-9.Review

    Pubmed

    2

    Baba, Y., Matsumoto, M., Kurosaki, T.

    Signals controlling the development and activity of regulatory B-lineage cells.

    Nat Immunol.

    2015 27(10):487-93.Review

    Pubmed

    1

    馬場義裕、黒崎知博

    「IL-10産生B細胞による自己免疫疾患の抑制」

    実験医学

    2015 Vol.33, 12:173-178

  • 2014-2011 selected publications

    10

    Matsumoto, M., Baba, A., Yokota, T., Nishikawa, H., Ohkawa, Y., Kayama, H., Kallies, A., Nutt, S.L., Sakaguchi, S., Takeda, K., Kurosaki, T., Baba, Y.

    Interleukin-10-Producing Plasmablasts Exert Regulatory Function in Autoimmune Inflammation.

    Immunity.

    2014 41:1040-51

    Pubmed

    9

    Ise, W., Inoue, T., McLachlan, J.B., Kometani, K., Kubo, M., Okada, T. Kurosaki, T.

    Memory B cells contribute to rapid Bcl6 expression by memory TFH cells.

    Proc. Natl. Acad. U.S.A.

    2014 111:11792-7.

    Pubmed

    8

    Shinohara, H., Behar, M., Inoue, K., Hiroshima, M., Yasuda, T., Nagashima, T., Kimura, S., Sanjo, H., Maeda, S., Yumoto, N., Ki, Sewon, Akira, S., Sako, Y., *Hoffmann, A., *Kurosaki, T., *Okada-Hatakeyama, M.(*co-corresponding authors)

    Positive Feedback Within a Kinase Signaling Complex Functions as a Switch Mechanism for NF-κB Activation.

    Science.

    2014 344:760-764.

    Pubmed

    7

    Baba, Y., Matsumoto, M., Kurosaki, T. 

    Calcium signaling in B cells: regulation of cytosolic Ca2+ increase and its sensor molecules, STIM1 and STIM2.

    Mol Immunol.

    2014  62:339-43.Review

    Pubmed

    6

    Kometani, K., Nakagawa, R., Shinnakasu, R., Kaji, T., Rybouchkin, A., Moriyama, S., Furukawa, K., Koseki, H., Takemori, T. and Kurosaki, T.

    Repression of the Transcription Factor Bach2 Contributes to Predisposition of IgG1 Memory B Cells toward Plasma Cell Differentiation.

    Immunity.

    2013 39, 136-147

    Pubmed

    5

    Kometani, K., Yamada, T., Sasaki, Y., Yokosuka, T., Saito, T., Rajewsky, K., Ishiai, M., Hikida, M. and Kurosaki, T.

    CIN85 drives B cell responses by linking BCR signals to the canonical NF-κB pathway.

    J. Exp. Med.

    2011 208(7), 1447-1457

    Pubmed

    4

    Matsumoto, M., Fujii, Y., Baba, A., Hikida, M., Kurosaki, T. and Baba, Y.

    The calcium sensors STIM1 and STIM2 control B cell regulatory function through IL-10 production.

    Immunity.

    2011 34, 703-714

    Pubmed

    3

    Yasuda T., Kometani, K., Takahashi, N., Imai, Y., Aiba, Y. and Kurosaki, T.

    ERKs Induce Expression of the Transcriptional Repressor Blimp-1 and Subsequent Plasma Cell Differentiation.

    Sci. Signal.

    2011 4, (169) ra25

    Pubmed

    2

    Baba, Y. and Kurosaki, T.

    Impact of Ca2+ signaling on B cell function.

    Trends in Immunol.

    2011 32(12)589-594 Review

    Pubmed

    1

    Kurosaki, T.

    Regulation of BCR Signaling.

    Mol. Immunol.

    2011 48, 1287-1291 Review

    Pubmed

大阪府吹田市山田丘3-1 大阪大学融合型生命科学総合研究棟 9F
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